Randomized Clinical Trial Comparing Oral Dydrogesterone to Micronized Vaginal Progesterone for Endometrial Preparation in Frozen-Thawed Embryo Transfer Cycle
نویسندگان
چکیده
Background: The objective was to compare the use of micronized vaginal progesterone 800 mg daily and oral dydrogesterone 40 in endometrial preparation for frozen-thawed embryo transfer (FET). Methods: Prospective randomized study with women undergoing FET along hormone replacement therapy preparation, between September 2019 February 2021. A total 73 patients were randomly selected orally received mg/day (DYD group, n = 36) or (MVP 37) after transdermal estradiol. main outcome a viable ongoing pregnancy 12 weeks gestation. Biochemical pregnancy, clinical live birth rates secondary outcome. Results: reproductive outcomes cycles similar, Live didrogesterone MVP treatment groups being respectively: Biochemistry (38.9%/37.8%; p 0.189 [95% confidence interval (CI) –23.4–21.2]), Clinical (33.3%/35.1%; 0.192 CI –20.0–23.6]); Weeks Pregnancy (33.3%/32.4%; 0.196 –22.4–20.6]); –22.4–20.6]). Conclusions: revealed similar results cycles. is reasonable option, may be more accepted by terms ease lower cost. Trial Registration: U1111-1247-1845.
منابع مشابه
Methods for endometrial preparation in frozen-thawed embryo transfer cycles.
Frozen-thawed (FT) embryo transfer is a procedure used for the storage and transfer of excess embryos obtained during in vitro fertilization- intracytoplasmic sperm injection cycles. In recent years, improvements in laboratory conditions and limitations on the number of embryos to be transferred have led to a progressive increase in FT embryo transfer cycles. However, the best solution for endo...
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ژورنال
عنوان ژورنال: Clinical and Experimental Obstetrics & Gynecology
سال: 2023
ISSN: ['0390-6663', '2709-0094']
DOI: https://doi.org/10.31083/j.ceog5001008